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Shiitake is the only mushroom that contains eritadenine — a compound that lowers cholesterol through a mechanism distinct from statins, by inhibiting the enzyme S-adenosylhomocysteine hydrolase and accelerating cholesterol excretion. Clinical trials using 9g/day of dried Shiitake report 7–12% reductions in total cholesterol and 6–7% reductions in triglycerides. Our 8:1 extract concentrates these compounds to therapeutic levels in a single capsule.

Shiitake Benefits:

• Cholesterol Regulation: Eritadenine accelerates the excretion and metabolic breakdown of ingested cholesterol. Because it works through a different pathway to statin medications, Shiitake may be a useful dietary supplement for those who are statin-intolerant or looking for complementary support. In clinical studies, daily consumption of dried Shiitake led to measurable decreases in both total cholesterol and triglyceride levels.
  
  
• Metabolic Function: Laboratory studies suggest Shiitake extracts may influence glucose metabolism, with data indicating reductions in plasma glucose levels and improvements in insulin response. Combined with its cholesterol-lowering properties, this positions Shiitake as a broad metabolic support — addressing lipid and blood sugar pathways through distinct mechanisms.
  
  
• Immune Support: Lentinan, Shiitake’s primary beta-glucan, is one of the most researched polysaccharides in mycology. It stimulates natural killer cells and macrophages, and is licensed as a pharmaceutical in Japan. Shiitake also shows consistently high antimicrobial activity in laboratory testing, including the strongest anti-candidal action among commonly studied mushroom species.
  
  
• Digestive Health: Shiitake contains 25–35% soluble and insoluble dietary fibre, including beta-glucans that act as prebiotics to support beneficial gut bacteria. This high fibre density, combined with its antimicrobial compounds, makes it a useful contributor to digestive function and microbiome diversity.
  
  
• Nutritional Profile: Beyond its bioactive compounds, Shiitake has an excellent nutritional base — high in B vitamins and pro-vitamin D2 (ergosterol), which converts to vitamin D when exposed to UV light. It’s the second most widely cultivated mushroom in the world, with a long culinary history that speaks to both its palatability and its track record as a dietary staple.

We supply one of the most concentrated Shiitake extracts available, clinically dosed and third-party verified for potency. Each capsule serving contains the dry-weight equivalent of 3,600mg of Shiitake.

The Functional Mushroom Company is committed to unparalleled standards—delivering scientifically substantiated, potent mushroom supplements. Each product is rigorously researched and ethically sourced, embodying our dedication to purity and efficacy for individuals who prioritise integral health and genuine quality